Search request: F KW OVALE AND ANTIFUNGAL
Search result:  12 citations in the Medline database

Display:  4 ABS

4. Faergemann J.
     Pityrosporum ovale and skin diseases.
   Keio Journal of Medicine, 1993 Sep, 42(3):91-4.
     (UI:  94076783)
     Pub type:  Journal Article; Review; Review, Tutorial.
     AT: UCSF  Library   W1 KE 381 Journals   1, 1952-
         (PE title:  Keio Journal of Medicine. Tokyo.)

Abstract: Pityrosporum ovale is a lipophilic yeast belonging to the normal
    human cutaneous flora in adults. It is not only a saprophyte but also an
    opportunistic pathogen associated with: Pityriasis versicolor, Pityrosporum
    folliculitis, seborrhoeic dermatitis and some forms of atopic dermatitis.
    Even systemic infections have been described. In pityriasis versicolor P.
    ovale change from the blastospore to the mycelial form under the influence
    of predisposing factors such as high temperature, high relative humidity or
    endogenous factors such as greasy skin, sweating, heredity,
    immunosuppressive treatment or disorders. Topical treatment is often
    effective but short term treatment with fluconazole, ketoconazole or
    itraconazole is also effective. The great problem is recurrence and to
    avoid this a prophylactic treatment is mandatory. Pityrosporum folliculitis
    is a chronic disease characterized by pruritic follicular papules and
    pustules located primarily on the upper trunk, neck and upper arms. Under
    the influence of the same predisposing factors as in pityriasis versicolor
    P. ovale increase in numbers in the hair follicles. The main differential
    diagnosis is acne vulgaris. The effect of antifungal treatment is often
    dramatic. There are now many studies indicating that P. ovale plays an
    important role in seborrhoeic dermatitis. Many of these are treatment
    studies showing a good effect of antimycotics parallelled by a reduction in
    number of P. ovale. Severe seborrhoeic dermatitis often difficult to treat
    is associated with AIDS. In a recent study we have evidence for a slight
    T-cell defect in many patients with seborrhoeic dermatitis.(ABSTRACT
    TRUNCATED AT 250 WORDS)